MP436ANTI PHOSPHOLIPASE A2 RECEPTOR ANTIBODIES IN DIABETIC PATIENTS WITH PROTEINURIA

Phospholipase A2 receptor antibodies in membranous nephropathy: unresolved issues.

The discovery of theM-type phospholipase A2 receptor (PLA2R) as a major antigen in idiopathic membranous nephropathy (iMN) was a breakthrough and established iMN as an autoimmune disease.1 Subsequent studies confirmed that antibodies against PLA2R were present in approximately 70% of incident iMN patients (reviewed by Hofstra and Wetzels2). The potential role ofmeasuring PLA2R antibodies for cl...

Effects of Folic Acid Supplementation on Proteinuria in Type 2 Diabetic Patients with Overt Proteinuria

Objective: An association between high homocysteine levels and proteinuria in diabetic nephropathy has been shown. On the other hand, supplementation with folic acid lowers homocysteine concentration. We have studied the effects of folic acid supplementation on proteinuria in type 2 diabetic patients with overt proteinuria. Materials and Methods: Forty five (29 men and 16 women) type 2 diabe...

Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies.

Serum phospholipase A2 in patients after splenectomy.

Phospholipase A2 values increase in serum in various inflammatory states, infections, and postoperatively in surgical patients. Several organs, including the liver and spleen have been suggested as sources of circulating phospholipase A2. The purpose of the present work was to examine the possible role of the spleen as a source of elevated serum concentrations of phospholipase A2 after surgery....

Anti-Phospholipase A2 Receptor Antibodies in Membranous Nephropathy: from Bench to the Patient

Membranous nephropathy (MN) is a glomerular disease histologically characterized by an uniform thickening of glomerular basement membranes (GBM) caused by subepithelial electrondense deposits of immune complexes, in which the antibody is an IgG. In about 2/3 of cases the etiology of MN is unknown and the disease is called primary or idiopathic. In the remaining cases MN may be secondary to syst...